I'm also very suspicious in believing that a Embraer in its light way of construction could bring down a solid built Boeing.
Think kinetic energy, not size/construction. Airliner fuselages are designed to be damage tolerant but aren't built to withstand high energy impacts. I'd say a full impact could be devastating. I'd imagine that even a clip could lead to loss of control and serious damage.
I think it's too early to speculate, as hard as that often is. The details will become apparent soon enough.
Thoughts are with the friends and families of the passengers.
V1R