Agree with Empty Cruise
....mostly agree with what Empty Cruise is saying.. But, I also feel that the simulator is just a big Playstation and part of you knows that. You can't re-create the pressure of a crappy dark night in the sim! Flying real aircraft where you feel a sense of self-risk is an important part of gaining confidence.
However, once trained and flying the line, experience is quickly gained flying the real aircraft. I reckon after 500 hours, you're initial training becomes a relatively minor factor.
However, (again) I don't think anyone should go ab-initio (conventional or MPL) into a long-haul job - not enough handling experience is gained when flying long haul. There should be some minimum like 1500 T/Os and Landings required before getting a job on a long-haul jet.