1) Weren't the runway lights on 22 off (failed) when the pilots arrived at LEX? I thought I saw an earlier post/news item saying exactly that.
Reflex... "oh, they still haven't fixed the lights"....
2) Looking at the airport diagrams and photos from the air, I had the impression that when taxying and lining up for take-off on either 22 or 26, the actual runway numbers (those painted on the runway, not the ICAO markers) would have been BEHIND them, so they would never have seen the actual runway numbers.
Please shoot me down if I'm wrong... it looked obvious to me, but nobody seems to have picked up on it.