Security is very important when staying in hotels, but remember that whatever keeps the bad guys outside your door, does the same with the good ones. I've witnessed before someone being incapacitated in his/her room being rescued. Two examples: a pilot who collapsed in his bathroom after an early wake up and badly hit his head. He was found unconcious after he didn't report for pick up and failed to answer the phone. He barely made it. If rescuers hadn't been able to get in quickly, he would surely have died. Second example, yours truly and meningitis. Although I was home at the time, I never forget that I'd be dead now if I had been home alone, since I didn't even realize I was ill before becoming unconcious.
Finally, as our PPRuNe Towers says "a good hardwood wedge kept in your suit case is both simple and effective".