This is, in no way, an attempt to prempt the results of the ongoing investigation. However (and in the meantime) ....
- It would be a relatively easy thing for airport operators to ensure that the runway numbers are painted in a position that is visible from the flight deck AFTER the aircraft has lined up. Looking at the available photos of 22 and 26 at KLEX I'm not at all sure that this is so today.
- All airlines as part of their SOP's should make it mandatory that crews check the DI with the Magnetic Compass and against the known runway direction BEFORE committing to takeoff.
No doubt someone will flame me for stating the obvious but, perhaps, it really does need to be stated (or re-stated) in the light of this tragic accident.