The answer has to be a very personal one...I am in a position with good money but no lifestyle...
I work 6-7 days a week, average 12 hours a day...but I have chosen to take this path, whilst I am still young (33!) for the next 10-15 years for both career progression and to build a nest egg for an easier time and better lifestyle later on
I am single and have no ties whatsoever...so it works for me.