cathay certainly has a Vancouver base BUT It will be hong kong first
Other non canadian airlines have pilots living in vancouver who use interline passes to "commute" to there required base. Knew a chap that worked for BA out of London but wife and kids lived in Vancouver. Seems less popular these days with most airlines getting more out of pilots duty wise per month than back in the day
As for major Canadian airlines you will need more than 1500TT to get a lookin
BUT you dont need to be a citizen to function as a pilot in any form.
You will need a work visa or be a landed immigrant to work though.
Good luck