I can't answer that question accurately but I would say not. Again this is just my hypothesis but I think the AOC's had been in place for some time and then a penny dropped somewhere in CAA HQ.
Some historians may be able to fill in some data here but I don't believe there have been many IoM based AOC operations at all. There was the original Manx Airlines of 1950's vintage and probably nothing then until Manx was reborn from the BMA/BUIA(?) venture in the 1980's. Several air charter companies have come and gone in the same period - I vaguely remember 1970's operators like Air Charter and Travel, City Air Links and IoM Flying Centre - but two had roots elsewhere and may well have been UK registered companies.
Just digging around the Net I see that Ravenair and Woodgate have aircraft based at Ronaldsway these days but both are UK operators. I've no idea where EuroManx have their AOC - possibly Austria as they use two Austrian registered Dash 8's.
I hope someone with more current knowledge may step in here as my association with Manx happenings ended some time ago. I am reasonably sure though that since revoking the Manx/IAT AOC's that none have subsequently been issued.