Wino, you're damn right that pac want to fly point-to-point. The way I see it though, there are 2 flaws in your plan:
1) Slot constrained airports (LHR, CDG, FRA, HKG, SIN etc.). The only way is with a bigger aircraft.
2) Let's say I want to go from, oh Humberside to Phoenix, say. How many other people want to do the same? So how much traffic, and at what yield, would there be? If we come down to it, then the ideal machine is a 737 or an A319 with the range to operate such routes. Then how many other aiports start to become slot constrained?
It's all very well saying that people want to fly point to point. It's true. I'd love not to have to make 2 stops from HUY to Sky Harbor. But there are finite airports with finite slots and finite ATC and airway capacity.
And we haven't even touched on the green-ness of a 757 vs an A380...