First of all mate, where are you?
I am in Oz. I have had aortic regurgitation all my life and held a class 1 since I was 17 (holy moses, 16 years!). CASA reserve the right to issue/refuse my medical to themselves these days, instead of letting my DAME OK it, but there will be no problem until I have a valve replacement.
Once I go on anti-coagulants the risk of sudden and total incapacitation greatly increases and I will be limited to "With or as a co-pilot only".
PM me for more info if you need.
Cheers
Horatio