Depends where in the USA. If you want to live on the East Coast in one of the 777 destination cities you'd probably have no problem doing back to back trips and commuting to the USA and you'd probably even get home on some of your trips, albeit for just one night. If you want to live further west then I'd say forget it as a junior pilot.
In terms of shorthaul flying, 2 hrs driving is do-able but not pleasant. You'll need to bid for long tours to cut the driving down, which as a junior pilot will mean long, early tours over weekends, but it can be done. Many of the cabin crew commute from further afield on a daily basis.