Though it may not make any PRACTICAL difference, it certainly can make a LEGAL difference...
In the 747F (200 or 400 -- doesn't matter except for specific numbers) all jumpseaters/upper deck occupants must be accounted for. At some point between 0 and 5 extras, the CG index will change by 1 unit. If the load is such that the airplane is at a forward CG limit, it can make a difference between a legal and illegal load.
In the situation in which I was involved, the CG was the limiting factor, not the weight.