An isolated destination doesn't necessarily mean a deserted island lonely somewhere in the ocean. It just means isolated: There is no other alternate available. In this sense certain ICAO countries call it island destination which is completly missleading.
It could happen that you fly to central Europe with isolated destination planning: If all airports are closed except one is open. You are allowed to fly there if certain requirements are met, i.e. airport open for a reasonable time, no danger that the airport will go closed, enough fuel to hold if something should happen.
Dani