Noblues,
I have used Ghost extensively in a corporate environment to build multiple PCs from a single (sysprepped) image.
If you use Ghost, you need to be able to store the image - this can be on another PC, or on CD. I know it used to be possible to span images over more than one CD, maybe it's possible now to write to DVD.
As long as you are aware that disk cloning is not really appropriate for backing up data, then go for it. To my mind, it is most useful for making an image of a PC once you have installed the OS and apps, and configured it as you want it, but before you start using it.
It makes taking regular backups even more important if your only recovery is to revert to day one!
In theory, you can set up 2 partitions on your disk - one for system, one for data - then Ghost the system partition, leaving the data intact.
The reality is that it is very, very difficult to keep all your data, application and personal configuration settings on the data partition.
It is also frighteningly easy to overwrite the data partition
SD