Wouldn't touch it myself. Especially spring/summer, when wx can cause major delays on flights at ORD. I'm going to Dayton in May, and to get there on Thursday, I'm flying to ORD on Wednesday and overnighting......been caught out too often with ORD's afternoon flights suffering wx cancellations.
Most of the UK flights from ORD go from K22/23/24 type area. Marvellous if you have a BA Gold Card 'cos the Flagship lounge is just round the corner.....
The only time I ever flew AA to GLA, we circled for an hour because of mist and diverted to Edinburgh. Then they didn't unload my bag!
Of course, if they will sell you the ticket and you don't care if you're late and re-routed..............