I would go to the regionals. You obviously aspire to a multicrew airline environment, so go and get some multicrew turbine time to show how keen you are, and to see if you enjoy it. Stick with the freight until you get the usual minimum command time experience required to take a command with the regional you are applying for though. No point in leaving until you have 1000 plus command hours. If you have got it, move on! Time waits for no man! (Or woman!)
Good luck! Regionals are a hoot! An awesome stepping stone to the majors.
Not to say airlines wont look at you with Islander time, they will. As soon as you hit the minimum experience requirements, regardless of what you are flying, thats the time to get the resume in.