Interesting question this. For the 757 the FCTM makes no mention of the effect of drag on takeoff run with cross controls. It does mention that "large control wheel inputs can have an adverse effect on directional control near V1 (MCG) due to the additional drag of extended spoilers"
It then goes on to mention that "Use of excessive control wheel may cause spoilers to rise which has the effect or reducing tail clearance"
In our airline we use a maximum of 2 units of control wheel displacement so as not to "pop" the spoilers, and this technique is taught throughout the fleet.