These days, (mainly travelling in and out of West and Central Africa) I tend to use Doxycycline. I was on paludrine/chorloquine for twelve years living in the bush in Ivory Coast: it didn't keep me completely free of malaria but living where we did and doing the job we did being free of malaria was always going to be difficult. My wife had a dreadful time for about eight years and its only when she switched to doxcycline that things really settled down for her. The chloroquine/paludrine thing never worked for her (and larium was worse).
It is well worth noting that if you are in a malaria area and you do get bitten, then malaria becomes a stress related disease. If you get really tired or stressed, then your prophylaxis will really struggle to deal with the parasites. If you are likely to be seriously exposed to palu, take a treatment with you everywhere you go (our family carry arsumax - even though we are mainly based in the UK now).