Spend serious time with AFM.
Know your density altitude
Pace out AFM ground roll on landing + safety factor from other end of runway and mark it -- if you're not in the air by that point, you have a reasonable chance to stop and reconsider without damage to a/c or people.
Work out distance to clear 50' obstacle and climb rate at density altitude to determine performance margins against terrain, especially if rising.
There is a takeoff performance computer available which can be used to take in account runway slope, weight and wind. Take with big grain of salt.
Remember that overruns are generally less likely to kill you than flying into something
