It worked for us !
Starting one month before moving into a malarial area, take 2 Paludrine tablets every day at breakfast time. Make this a religious obligation. Do not fail ! Ensure your staff put the Paludrine on the table first thing every morning. If Sunday is a day off, have them put it out on Saturday night. Especially important for bachelors, who are notorious for forgetting - especially when p******d. Keep a backup supply in the meds cupboard.
2 tablets for adults, one tablet for children. Every day, without fail, even when on leave, and continue for at least two months after final departure from the area.
Close bedroom windows and doors at about 4.00 pm, spray rooms and landings/corridors. Erect mosquito nets and spray INSIDE the nets. If you have airconditioning, turn it on as early as you can.
Work out an "air-lock" system, or screening to keep mosquitos out of the treated areas.
Out of doors, especially in the evenings, mosquitos will zero in on any bare flesh, and below knee height they just love drilling through socks and stockings. No longer fashionable, but there was a good rationale for mosquito boots. Spray vulnerable areas with "Off", or similar repellant. The good stuff is harmless to skin or fabrics.
Avoid the weekly prophylactics ( SundaySundayMedicine as it was known). Miss one dose and you have lost a week's protection. Miss one dose of Paludrine and you have only lost a day. But if you do decide to go weekly, NOT Sunday ! Too easy to forget after a good Saturday night.
Whatever happens, you are going to get bitten, and malaria is going to get into your bloodstream. Paludrine will keep the parasites suppressed and help prevent the development of full blown malaria - which at best is very unpleasant and at worst fatal.
In most cases, after leaving the area ( and maintaining prophylaxis for a while), the parasites will die off. However, it might be a good idea to carry a card in the wallet to say you have lived in a malarial area, should you be found in distress.
My wife and I plus three small children lived in tropical Africa for 12 years, and the above regime kept us perfectly protected.
p.s. Keep a tube of Anthisan handy - the bites itch like hell !