As already mentioned, EZY, from here to there is no problem. To make it simpler you want an aircraft with 1,000nm still-air range. With less than that you need to go to Vagar, Kulusuk and (probably) Frobisher or get a tank. Standard route westbound is Wick, Reykjavik, Narsarsuaq, Goose.....for ease and financial reasons.
An IFR fit and rated pilot also make things simple......VFR is allowed but why make it tough on yourself?
Single engine you will need a bit more safety gear - you must also wear an immersion suit when flying.
PFA is even OK if you do the extra paperwork.
People do it every week....I have been across in about 8 singles, both directions, piston and turbine. The next will probably be in a few weeks.
It's fun.