Depends on the pilot and the job, known a few pilots in their 60s who could run a marathon and were far better physical condition than many 30 years younger. I probably wouldn't want 4-5 sector days in busy airspace, or unusual hours. But a 2-3 day week all daylight in good weather conditions appeals.
If it's still around in 20 years time a senior captains job were you draw full pay and bid reserve the whole time, only flying once a month to stay current would suit.