BMM,
there will be no shortage of people here willing to help you, but you must be more specific. Precisely what sort of machine is it (processor/motherboard)? Is there room for an extra drive? Have you looked at the IDE (I presume it's IDE and not MFM or ESDI

) cable to see if there is a spare port on it? Which operating system is being used? Are you replacing the old drive or supplementing it?
As Binos said, anything made after 2000 will fall somewhere between dead easy and magic. Before 2000 can be ... interesting with the high-capacity modern drives.
BOFH