Interesting isn't it? Only a year ago, Spyware/Adware/Malware was a subject fit for only Geeks. The most important thing in my book is not which prog to run (Though I use MS and am happy with not only it, but the host of tools it brings with it) but that you are aware of the problem.
That same awareness will lead to a thought bubble when you browse certain net areas and that in itself is the biggest enhancement to the safety of your PC. When reaching that state of enlightenment, hit it with everything you can. Only proviso, is that running more than one program, can give rise to spurious alerts, as prog A has quarantined a few suspect bits and prog B reports same quarantine as being almost 100% spyware.
Think about it
Conan