I would be interested to know what type of scanner you are using and the soft that gives that choice
Nikon Coolscan V hardware with Nikon Scan 4 scanning software (although I merely use that for capture and process using Photoshop Elements). All very good (complete with dirt/mark reduction processing) ... so good infact that there is a part of me that questions whether the alternative settings are an unnecessary complication. However, with 25 years worth of slides to scan, I am keen to get it right at the outset!