Cabin/cockpit altitiude does not change in the Sim....as it does in the actual aircraft.
If some of the volunteers were masked and some unmasked then the effects of the loss of pressure...and such could be measured...compared to theories...etc.
I can see some benefit to a re-enactment as it relates to the investigation. However it would appear the long list of questions that would remain far outweigh what benefit the reenactment would answer. It almost sounds like a few pages out of a Richard Wambaugh novel where the detectives tried to reenact their theory that would turn a murder into a suicide and thus solve the case quickly. Wambaugh described a situation where the cops fired a Colt .45 over a thousand times to get a single spent shell casing to land on top of a wardrobe in order to prove their convenient theory.
Is this what is going on here....pick an answer and find the evidence to support it?