Thinking of the advanced tech and A380 I assume you will see more of this debate with 787 and A350 then on A380.
What is really "new technology" on 380 is very questionable. Size is not the matter, apart from the operational side (passenger loading/unloading) - meaning that this size of a/c are flying for some time (see the issue of vortex generation).
Anyway new technologies will appear with 787 and 350 so let us see how good will be the application of stuff used on CFR 23 built models (GA, some of the business aviation models) in large commercial type a/c.
What I specifically mean is the new engine and the all-composite fuselage of that size.
To claim for that absolute safety (and reliability) will be a challenge.
For 380 it is quite a safe estimate.
Cheers,