I had an interesting experience many years ago when I had to flight test a PA28 modified to be flown by a paraplegic pilot! This had an interesting arrangement where a two axis hand control on the left was throttle and rudder, with a standard control wheel for your right hand. It worked a treat, and many paraplegics got a PPL. The hardest thing for them to gain the licence was having to demonstrate an unaided evacuation, while the hardest for me was getting the hang of crosswind landings!
But seriously, the main point here is that humans are highly adaptable and will cope with whatever configuration the designers come up with. They will then amuse themselves endlessly arguing over which configuration is best
