I don't know whether this one is Fact, Fiction, or Folklore, but I was told (by an alcoholic AME) that the extra mule's kick of a red wine hang-over was due to the high level of hystamines in red wine. His recommendation was to use a few anti-hystamines 'the morning after' to combat this, and convert the mule's kick red wine hang-over into a normal hang-over.
Perhaps Captain Claret can shed some light on this?
Regards (hic),
Old Smokey