While the MEL allows dispatch with both aoutopilots u/s it is necesary to keep your handflying skills current. You can be asked at any time (and I have a few times) to handfly two or more sectors, sometimes into cat C airfileds, sometimes in challenging weather conditions often tired after a long day. Is this the time to start relearning old skills?
This also applies to circling approaches, TCAS RA'S, Winshear and GPWS scape maneuvers, failure of the automatics to operate normally without even going into elaborate hydraulic or electric failures.
Handflying skills are still required in an airline environment, at least for now.