If you just go through the posts of this forum you can easily find several pilots working for some LoCo airlines who are really under pressure, they are worried: sometimes they are stretched to the limit. They admit this.
Nobody is trying to say that LoCo means Low safety but the pressure is definitely there in some cases, obviously not only within LoCo companies: denying this is simply criminal.
Pilots who have been in the industry for many years have often noticed a change in "policy" in recent years, and some engineers can confirm this too.
The pressure is not limited to one country or one carrier, it is just a general industrial change which has affected the commercial aviation industry in recent years, especially after privatisations.
Pressure can be present in many forms, direct or indirect, e.g. rosters, scheduling, motivation, HR etc.
Example: a tough roster can indirectly put too much pressure on pilots, and this might affect safety.
As simple as that.