When the world goes over to VHF standard comms!
Well, not across the oceans!
Eventually, the IRP/GPS will make position/velocity reports directly via satellite to the ground system that will have control of the flight. That system will then relay course commands. Airborne human input = zero.
The only human input task will be to steer the a/c to/from the gate/runway.
You've all seen the Global Hawk. Just scale it up & put seats in it.
The Odd One