Saskatoon - that depends!
My company used the FL100 two-engine scenario as worst case for the B763, but FL100 single-engine as worst case for the A332.
However, I believe that at certain speeds, depending on engine type, FL100 two-engine is worst case for the 330!
Old Smokey- I'm not familiar with 3 or 4 eng LROPS - is Depress/Eng Inop fuel mandated by the regulator when operating in certain areas, or is it a company (or common sense!) requirement?