Only flying a wee pacey jet here but it's sufficiently different from my last aeroplane to offer a suggestion.
With short haul intra Europe you've got lots of alternates handy and generally you'll be in tune with the wx as you're in the same relative area. Time zones aren't too much of a problem and you're doing multiple legs.
From what I can see the long haul operation is different in the mindset. Your destination is half a day away and the weather can be completely different to what you're experiencing. eg Summer v Winter etc.
Also there's the issue of alternates. They aren't right next door only 20-30min flying time away, they could be a fair few hours away (eg Perth, Australia) and that requires a bit more planning.
I dare say staying motivated and awake is also a challenge too.