Already a MAN - London City route on VLM
MAN to Luton not tried recently but cant see it being very popular as dont think Stansted is.
MAN - Cardiff was tried by Air Wales a few years ago but not well marketed - could workl
MAN- Newcastle again could easily work (BMI, Eastern, FlyBe or Easyjet?)
MAN - Birmingham - no chance!
Other routes I could see working from Manchester
Twice daily Exeter (Flybe?)
Bournemouth (Eastern?) - but maybe too close to Southampton
Swansea (Air Wales) - 4hr drive
Newquay (direct- maybe bmibaby next summer)
Prestwick (Ryanair/Jet2)
Southend? Brighton??