On the Challengers anti-skid inop is a no-go item. The manual states that virtually any application of brakes over 80knots will blow the tyres without it. It happens every time in the sim, but luckily I haven't tried it in the aeroplane.
As an aside, I always used to laugh at the preamble to the old CAA MEL's, which described the scenario of an engineer trying to persuade a pilot to delay his flight so that the item could be fixed while the pilot wanted to take the aircraft as it was...!??
