Besides the points already mentioned, one of the biggest hurdles I remember were the much shorter stage times on flights ie. the time between one waypoint and the next, which meant having to speed the thought processes up to stay ahead of the aeroplane.
I think my brain finally caught up with my a_hole after about 6 weeks, during the initial jet conversion (from F27 to DC9).
The extra honeys down the back were another distraction that compounded the conversion.
(That might be the Phase 4
Old Smokey is looking for - can you imagine the variety on an A380
)