Hmmm, spent many hours in pursuit of the perfect piece of luggage, currently use a variety of bags according to length of trip.
Samsonite hard shell with built-in suit carrier - Long Haul or > 4 nights
Samsonite soft-sided carry-on for up to 4 nights, laptop bag slips over handle
Travel Gear combined carry-on with laptop pouch for over-nighting
Still looking, for us luggage-istas, there's always a better bag out there