Also folks I would not get too concerned with the opening line - after all if a company is going to hire you/interview you just by your opening line what does that say about it as a company and as an equal opportunity employer?
Very true. But the opening line will not get you a job or interview, it
may get the reader to read the rest of the letter, which
may then be removed from the mountain of applications and put in the 'maybe' pile, rather than the bin.
At some stage the reader will re-read it, and the opening line
may again help the letter get from the 'maybe' pile into the 'interview' pile.
The reader may then decide there are too many in the 'interview' and read them again, probably just the first few lines this time. Once again the opening line will play a crucial role, and may keep the letter in the 'interview' pile, and you will be invited to interview.
Only then does the opening line lose its importance.