I´m a leftie...
never found any problems within the actual handling bit, but quite a few of my colleagues are amazed at the fact.
"Are u left handed" (with a seriously amazed voice)
Surely they must have met one or two lefthanded persons before.
Another good one
"How does it feel to be lefthanded"
Dunno, sort of used to it ya know.
I write with both hands, but only tend to use my left hand anyway, run the computer mouse with my right to avoid changing every its position every flippin time.
What irritates me is my inability to use right hand siccors, I just can cut a straight line with ´em.