I visit full mo sims regularly and most recently flew a VS346 at gecat and was terrified at the prospect of flying the stick with my left hand (same sort of problem just reversed.)
However, I was totally amazed at the abilty to switch with no thought at all including commanding the throttles with a hand that is more used to orbiting a stick base
The F/O who was in with me on the sim showed me my approach analysis and said an instrument rating would be more than achieved from the resulting data.
It seems that when it actually comes to the crunch your brain takes over rather than your dexterity.
I flew in all weathers and found it to be an incredibley enlightening experience.
But just maybe that's the aircraft rather than the driver?
Mark.