One of the things I found annoying was that after a scan my home page would be reset to the MSN homepage.
The solution to this, if it happens, was posted by one of the members of another forum:
"The problem with your start page being reset is most likely do to a setting in the "Advanced Tools - Restore Hijacked Internet Explorer Settings" window.
From the main AntiSpyWare window select: "Tools-Advanced Tools-Browser Hijack Settings Restore".
It is my understanding that any boxes that are ticked in this window will be restored to the settings shown when a scan is done.
ie. "about:blank" restored to "http://www.msn.com"
At the bottom of the "Details" window on the right you should see a selection to "Change the restore setting to a new URL...".
You can change any of these settings to reflect your own personal default prefs. Then tick the appropriate box to allow AntiSpyWare to to protect your personal settings."
After thinking about it I assumed that the program may cover the possibility that the home page it sees could be a hi-jacked one and you need to tell it otherwise.
So far I have not had any real problems with it and between AdAware, Spybot and the MS program they all seem to catch something that the other misses.