you should know your requirements better.
can say you just one thing: you can feel free to choose any TWO of these three points:
1. take-off from 5000ft rwy
2. go for 5000 nm (even with techstops)
3. have competitive per-kilo rates.
that kind of operations are normally done with a feeder fleet, feeding fish to some closest hub with a scheduled maindeck capacity or to some airport where it can be loadaded on widebody freighter. otherwise you are not competitive.