The BE76 Duchess is my preffered weapon of choice. I fly it around 150hrs a year and she is gracefull lady if a little slow compared to other twins.
I dislike intensly flying the Sennecca and avoid it unless there is no other option! The one I have access to is a Sennecca 201 Turbo, it goes OK but is very heavy in pitch.
The twin commanche is lovely to fly but a bit long in the tooth. The 310Q was also nice to fly.
The weirdest I have flown was the Aerostar, very twitchy and cramped, like a 6 seater 152!