Hi UTR,
I am not a CASA AME but would reason that if you are fit enough and have the required strength to fly on a class 2 then I can not see why you would not fullfill the requirements for a class 1.
After all in principle both allow you to fly twins.
The FAA and the CAA (UK) have some differences in requirements and standards that have to be met for the different classes but none is related to strength in legs/arms.
I doubt whether there is much case study work available as your case will be pretty unique and as such it will come down on your specifics and the view that the certifying authorities will take.
Can't say anything sensible about employability after getting your tickets. Over here it would be difficult not to employ someon for having a scar on their leg if they are otherwise suitably trained and qualified.