I guess it depends what kind of flying you do - if it is short haul and you need to be at work every day for a week, then you will need to keep a flat or room near work then head off back home for your days off.
Long haul will be easier - if you're working for a week or so then off for another week, then it is more practical to go home for the week then fly back in when you are next on duty, so you may not need to keep a room near work.
Having two homes is expensive, so I guess it can be done it just depends on how much you want to spend and how long you want to spend travelling!