In my limited experience with the 280C, I found it to be safe and predictable in flight. It was also demanding maintenance-wise, but if you took good care of it, it took good care of you. Drag dampers could be a source of irritation, but the only engine-stopper in the aircraft I was involved in came from a failed fuel-injection system.
When using it for training, the CFI must watch boost and RPM carefully, and monitor EGT and CHT as well, otherwise stuck and failed valves are likely (I saw one of those).
However, there's a very solid feeling to the aircraft, and they auto very nicely. The turbocharger is great in the mountains, and the ship is comfy for two and luggage.