Have operated transPacific with three and four engine jets, and the DC6B and 1649A.
Early types had 4 engines because they needed 'em, such was the reliability...and power requirements.
Don't see how the 4 engine types will survive such is the economics/reliability of twins.
Take the route SFO-HNL for example.
No off-route diversion airfields available...and yet the only type to get a wet footprint on that route was a Stratocruiser (lost two)...a very long time ago.
All survived as it ditched alongside OS November.