Did my CPL in the US of A and seem to be doing alright on my IR back in the UK.
Only issue that I haven't noticed anyone mention is the a/c change. If you are doing all your training at one school you will presumably use the same a/c for your CPL/Multi rating and IR. If you are like me you will fly one type of multi in the US and have to get used to another whilst entering the world of numbers and dials.
Personal preference as to whether time and money offset this extra workload- it works for me but it is something else to think about while deciding what works for you.
Good luck either way