Space travel is inherently dangerous. One of the mistakes NASA made during the Shuttle era was to treat missions after the first four as ‘operational’ rather than test flights. This mindset, in my opinion, is where danger lies.
I believe it’s important, even essential to treat each space mission as a test mission and that danger lies within.
I would hope that most astronauts are keenly aware of the risk and in some respects accept that they may die. I recall that Christa McAuliffe was asked about the risks before she set off on 51L and she stated that spaceflight was pretty routine at that point. It always struck me that, if she truly believed that and that Scobee, for example, hadn’t had a frank discussion with her, that it was a great shame that she was not aware before she died.
Certainly many Orbiter commanders were very aware of the inherent danger, including John Young, Hoot Gibson and others.
Integrity was a great name for Artemis II, for me, because it’s one thing the Orbiter never appeared to have. I always had the feeling of fragility, post Challenger, whenever they launched. I do believe that going back to a capsule system is prudent.
On another subject, I do wonder how interest in Artemis will fare with such big gaps between missions. Especially as III will be an Earth orbital mission and somewhat lacking interest for Joe Public?